A NOVEL METHOD FOR THE REDUCTION OF AZIDES TO AMINES USING POLYMER SUPPORTED FORMATE AND MAGNESIUM
Keywords:Azides, Polymer supported formate, Magnesium, Amines, Catalytic transfer hydrogenation.
A novel and efficient method for the reduction of both aliphatic and aromatic azides to corresponding amines using recyclable polymer supported
formate as hydrogen source and inexpensive magnesium powder as catalyst in methanol at room temperature is described. It reduces a variety of
aliphatic and aromatic azides to corresponding amines in presence of various sensitive functional groups such as halogens, carbonyl, ester, amide,
methoxy, carboxyl, phenol and hydroxyl, which are compatible with the present system.