https://ijcr.info/index.php/journal <p>International Journal of Chemistry Research (IJCR) is a peer-reviewed, open access journal, published by Innovare Academic Sciences Pvt Ltd. It publishes Research Articles, Short communications and Review Articles in all areas of chemistry.</p> <p>Authors can submit complete unpublished and original works, which are not under review in any other journals. The scopes of the journal include, applied chemistry, inorganic chemistry, analytical chemistry, organic chemistry, physical chemistry, structural chemistry, polymer chemistry, nuclear chemistry, chemical engineering, environmental chemistry, medicinal chemistry and pharmaceutical chemistry.</p> <p><strong>Indexing and Abstracting-</strong>&nbsp;OAI, LOCKKS, Google Scholar, OCLC (World Digital Collection Gateway), UIUC</p> en-US [email protected] (Editor) [email protected] (Support) Tue, 01 Apr 2025 00:00:00 -0400 OJS 3.3.0.4 http://blogs.law.harvard.edu/tech/rss 60 https://ijcr.info/index.php/journal/article/view/248 <p><strong>Objective: </strong>The aim of the research is to synthesize and characterize Cu(II) and Mn(II) complexes with a Schiff base ligand and evaluate their antibacterial and antifungal properties.</p> <p><strong>Methods: </strong>The ligand was synthesized by refluxing 2-amino-4,6-dimethylpyrimidine and 5-Nitrosalicylaldehyde in ethanol, forming a yellow-orange product. The complexation reaction involved stirring ethanolic solutions of Cu(II) and Mn(II) salts with a Schiff base ligand. Thermal decomposition of Cu(II) and Mn(II) complexes was analyzed under nitrogen, heating at 30 °C/min, measuring weight loss from ambient temperature to 1000 °C. The antibacterial activity, antioxidant properties, and cytotoxicity of the synthesized compounds were examined using reported methods.</p> <p><strong>Results: </strong>Cu(II) and Mn(II)complexes with a Schiff base ligand were synthesized. Analyzed through Fourier-transform infrared spectroscopy (FTIR), Ultraviolet-visible (UV-vis) and physiochemical tests and confirmed the structures. Magnetic susceptibility and electronic spectra suggested geometries supported by thermogravimetric data. Antibacterial tests revealed complexes had higher activity than ligands and also showed antifungal properties. The ligand and its complexes were screened for their antifungal and antibacterial activity against <em>Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme</em><em>, </em><em>Aspergllus flavus </em>and<em> Escherichia coli, Salmonella typhi, Staphylococcus aureus, B. subtilis.</em> The result indicated that the complexes exhibited good antifungal and antibacterial activities.</p> <p><strong>Conclusion: </strong>Cu(II) and Mn(II) Schiff base complexes were synthesized, showing octahedral geometries. They exhibited thermal stability and strong antibacterial activity, antifungal outperforming the ligand alone.</p> D. T. SAKHARE Copyright (c) 2025 D. T. SAKHARE https://creativecommons.org/licenses/by-nc/4.0 https://ijcr.info/index.php/journal/article/view/248 Tue, 01 Apr 2025 00:00:00 -0400