International Journal of Chemistry Research <p>International Journal of Chemistry Research (IJCR) is a peer-reviewed, open access journal, published by Innovare Academic Sciences Pvt Ltd. It publishes Research Articles, Short communications and Review Articles in all areas of chemistry.</p> <p>Authors can submit complete unpublished and original works, which are not under review in any other journals. The scopes of the journal include, applied chemistry, inorganic chemistry, analytical chemistry, organic chemistry, physical chemistry, structural chemistry, polymer chemistry, nuclear chemistry, chemical engineering, environmental chemistry, medicinal chemistry and pharmaceutical chemistry.</p> <p><strong>Indexing and Abstracting-</strong>&nbsp;OAI, LOCKKS, Google Scholar, OCLC (World Digital Collection Gateway), UIUC</p> Innovare Academic Sciences Pvt. Ltd. en-US International Journal of Chemistry Research 0976-5689 ISONICOTINOHYDRAZIDE DERIVED SCHIFF BASE–TRANSITION METAL COMPLEXES: STRUCTURE WITH BIOLOGICAL ACTIVITY <p><strong>Objective: </strong>Antimicrobials are medications used for preventing and treating infectious diseases in humans, animals, and plants. Antimicrobial resistance is increasingly becoming a prominent global public health and developmental concern. The primary aim of this study is to synthesize metal complexes with superior antimicrobial properties.</p> <p><strong>Methods: </strong>The Schiff base ligand (E)-N'-(1-thiophen-2-yl) ethylidene isonicotinohydrazide was synthesized by reacting isonicotinohydrazide (INH) with 2-acetylthiophene. This Schiff base was utilized to synthesize metal complexes with copper (II), nickel (II), and cobalt (II) ions via the reflux method. The ligand and metal complexes were characterized using various physicochemical techniques, including elemental analysis, conduct metric studies, magnetic susceptibility, FT‐IR, 1H NMR, ESI-MS, and electronic spectral analysis.</p> <p><strong>Results: </strong>All complexes were successfully characterized. The Ni-complex demonstrated the highest cytotoxicity in the brine shrimp lethality bioassay compared to the Cu and Co-complexes. The Ni and Cu-complexes exhibited greater antibacterial efficacy against all bacteria, while the Co-complex showed no activity.</p> <p><strong>Conclusion: </strong>The newly synthesized complexes proved to be highly stable, displaying significant antimicrobial potential. These findings suggest that future modifications to this synthesized series could address specific pharmaceutical needs.</p> AL AKRAMULLAZI SABIHA SULTANA FARUK HOSSEN ALI ASRAF KUDRAT-E-ZAHAN Copyright (c) 2024 AL AKRAMULLAZI, SABIHA SULTANA, MD. FARUK HOSSEN, MD. ALI ASRAF, MD. KUDRAT-E-ZAHAN 2024-07-01 2024-07-01 1 9 10.22159/ijcr.2024v8i3.230