International Journal of Chemistry Research
https://ijcr.info/index.php/journal
<p>International Journal of Chemistry Research (IJCR) is a peer-reviewed, open access journal, published by Innovare Academic Sciences Pvt Ltd. It publishes Research Articles, Short communications and Review Articles in all areas of chemistry.</p> <p>Authors can submit complete unpublished and original works, which are not under review in any other journals. The scopes of the journal include, applied chemistry, inorganic chemistry, analytical chemistry, organic chemistry, physical chemistry, structural chemistry, polymer chemistry, nuclear chemistry, chemical engineering, environmental chemistry, medicinal chemistry and pharmaceutical chemistry.</p> <p><strong>Indexing and Abstracting-</strong> OAI, LOCKKS, Google Scholar, OCLC (World Digital Collection Gateway), UIUC</p>Innovare Academic Sciences Pvt. Ltd.en-USInternational Journal of Chemistry Research0976-5689ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXICITY STUDY OF Cu(II), Zn(II), Ni(II), AND Zr(IV) COMPLEXES CONTAINING O, N DONOR SCHIFF BASE LIGAND
https://ijcr.info/index.php/journal/article/view/231
<p><strong>Objective: </strong>The aim of the research is to synthesize and characterize Cu(II), Zn(II), Ni(II), and Zr(IV) complexes with a Schiff base ligand, and evaluate their antibacterial and antioxidant properties.</p> <p><strong>Methods: </strong>The ligand was synthesized by refluxing salicylaldehyde with <em>o</em>-phenylenediamine in ethanol, forming a yellow-orange product. The complexation reaction involved stirring ethanolic solutions of Zn(II), Cu(II), Ni(II), or Zr(IV) salts with a Schiff base ligand. <br />Thermal decomposition of Zn(II), Cu(II), Ni(II), and Zr(IV) complexes was analyzed under nitrogen, heating at 30 °C/min, measuring weight loss from ambient temperature to 800 °C. The antibacterial activity, antioxidant properties, and cytotoxicity of the synthesized compounds wereexamined using reported methods.</p> <p><strong>Results: </strong>Cu(II), Zn(II), Ni(II), and Zr(IV) complexes with a Schiff base ligand were synthesized. Analyzed through Fourier-transform infrared spectroscopy (FTIR), Ultraviolet-visible (UV-vis) and physiochemical tests and confirmed the structures. Magnetic susceptibility and electronic spectra suggested geometries, supported by thermogravimetric data. Antibacterial tests revealed complexes had higher activity than ligands, and also showed antioxidant properties.</p> <p><strong>Conclusion: </strong>Cu(II), Zn(II), Ni(II), and Zr(IV) Schiff base complexes were synthesized, showing tetrahedral or square planar geometries. They exhibited thermal stability and strong antibacterial activity, outperforming the ligand alone.</p>SAJIB HOSSAINASHRAFUL ISLAMFARIA TASNIMFARUK HOSSENKUDRAT E-ZAHANALI ASRAF
Copyright (c) 2024 SAJIB HOSSAIN, ASHRAFUL ISLAM, FARIA TASNIM, FARUK HOSSEN, KUDRAT E-ZAHAN, ALI ASRAF
https://creativecommons.org/licenses/by-nc/4.0
2024-10-012024-10-0111110.22159/ijcr.2024v8i4.231THE INDUSTRIAL IMPORTANCE OF TECHNOLOGY TRANSFER FOR ANALYTICAL METHOD DEVELOPMENT AND VALIDATION–APPLICATION TO VILAZODONE HYDROCHLORIDE DOSAGE FORM
https://ijcr.info/index.php/journal/article/view/235
<p><strong>Objective: </strong>The research aims to create a fast, economical, and efficient tech transfer method for analyzing bulk materials and pharmaceutical dosage forms.</p> <p><strong>Methods: </strong>The analysis was performed using an Acquity UPLC BEH C18 analytical column (130 Å, 1.7 µm, 3 mm x 100 mm) with detection of the analyte at 238 nm. The mobile phase flow rate was optimized at 0.3 ml/min, and an injection volume of 0.5 µl** was used. The isocratic mobile phase consisted of a blend of buffer (0.1% OPA) and acetonitrile at a ratio of 40:60% v/v.</p> <p><strong>Results: </strong>All validation parameters of the analytical method were acceptable. The analyte eluted at 3.08 min with satisfactory theoretical plates and a tailing factor. The recovery of the analyte was 99-100%, and the method's precision was 0.59 and 0.72% RSD. The technique showed no interference, indicating specificity. The linearity was demonstrated over the 20-60 µg/ml range, with a regression coefficient of 0.999.</p> <p><strong>Conclusion: </strong>The developed method is cost-effective, specific with minimal interference, and time-saving. It also reduces solvent consumption for quality control analysis of vilazodone hydrochloride samples. The method demonstrates good linearity, robustness, and accuracy.</p>PULAGURTHA BHASKARARAOMATTA SARIKACHITRA LAKSHMI MADHAVIMOHAN GUPTA KOLLIPARAGUNTUR PRASHANTHI
Copyright (c) 2024 PULAGURTHA BHASKARARAO, MATTA SARIKA, CHITRA LAKSHMI MADHAVI, MOHAN GUPTA KOLLIPARA, GUNTUR PRASHANTHI
https://creativecommons.org/licenses/by-nc/4.0
2024-10-012024-10-01121710.22159/ijcr.2024v8i4.235