SYNTHESIS OF 5­ARYLIDINE­2­(3, 4, 5­TRIMETHOXYPHENYL)­3­(4­PHENYLTHIAZOL­2­YL) THIAZOLIDIN­4­ONE DERIVATIVES AS A NOVEL CLASS OF ANTIMICROBIAL AGENTS

Authors

  • D. CHANNE GOWDA Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore­570 006
  • K. C. PRAKASHA Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore­570 006,

Keywords:

2‐Amino‐4‐arylthiazole, Antimicrobial activity, 5‐arylidine, 4‐Thiazolidinone and 3,4,5 trimehoxybenzaldehyde.

Abstract

The present work describes the synthesis and in vitro antimicrobial evaluation of 5‐arylidine derivatives of 2‐(3, 4, 5‐trimethoxyphenyl)‐3‐(4‐
phenylthiazol‐2‐yl) thiazolidin‐4‐one (4). The reaction of 2‐amino‐4‐phenylthiazole, 3,4,5 trimethoxybenzaldehyde and mercaptoacetic acid in
presence of DCC yielded 2‐(3, 4, 5‐trimethoxyphenyl)‐3‐(4‐phenylthiazol‐2‐yl) thiazolidin‐4‐one (4) and further 5‐arylidne derivatives (5a­5k)
were synthesized by the subsequent reaction of 4 with different aryl aldehydes. All the synthesized compounds were characterized by standard
spectroscopic techniques, evaluated their antibacterial and antifungal activity by agar well diffusion method. The compounds showed some
interesting antibacterial activity. The substitution of 5‐arylidne groups on new thiazolidinone (4) have resulted enhanced antibacterial activity. The
compounds showed moderate antifungal activity in a scattered manner.

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Published

01-01-2011

How to Cite

GOWDA, D. C., and K. C. PRAKASHA. “SYNTHESIS OF 5­ARYLIDINE­2­(3, 4, 5­TRIMETHOXYPHENYL)­3­(4­PHENYLTHIAZOL­2­YL) THIAZOLIDIN­4­ONE DERIVATIVES AS A NOVEL CLASS OF ANTIMICROBIAL AGENTS”. International Journal of Chemistry Research, vol. 2, no. 3, Jan. 2011, pp. 10-14, https://ijcr.info/index.php/journal/article/view/35.

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Section

Research Article