DEVELOPMENT AND VALIDATION OF A UV­VIS SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION AND DEGRADATION MONITORING OF CEFADROXIL IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Authors

  • SUDDHASATTYA DEY Guru Nanak Institute of Pharmacy, Hyderabad
  • K. KALYAN Guru Nanak Institute of Pharmacy, Hyderabad
  • B. SAMYUKTHA Guru Nanak Institute of Pharmacy, Hyderabad
  • SUDHIR KUMAR SAHOO Royal College of Pharmacy and Health Sciences, Berhampur.
  • SUBHASIS MOHAPATRA Royal College of Pharmacy and Health Sciences, Berhampur.
  • P. N. MURTHY Royal College of Pharmacy and Health Sciences, Berhampur.
  • DHIRAJ KUMAR Royal College of Pharmacy and Health Sciences, Berhampur.

Keywords:

Cefadroxil, antibiotic, λmax, ICH, UV‐Vis spectroscopy

Abstract

The aim of the present work is to develop a simple accurate, precise and cost effective UV‐Vis spectrophotometric method for the estimation of
cefadroxil, a first generation cephalosporin an anti‐biotic drug, in bulk and pharmaceutical dosage form. The solvent used was methanol and
distilled water (50:50) and the λmax or the absorption maxima of the drug was found to be 264nm. A linear response was observed in the range of
10‐50µg/ml with a regression coefficient of 0.9999. The method was then validated for different parameters as per the I.C.H. (International
Conference for Harmonization) guidelines. This method can be used for the determination of cefadroxil in quality control of formulation without
interference of the excipients. Cefadroxil was subjected to stress degradation under different conditions recommended by ICH. The samples
generated were used for degradation studies using the developed method.

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Published

01-01-2010

How to Cite

DEY, S., K. KALYAN, B. SAMYUKTHA, S. K. SAHOO, S. MOHAPATRA, P. N. MURTHY, and D. KUMAR. “DEVELOPMENT AND VALIDATION OF A UV­VIS SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION AND DEGRADATION MONITORING OF CEFADROXIL IN BULK AND PHARMACEUTICAL DOSAGE FORMS”. International Journal of Chemistry Research, vol. 1, no. 1, Jan. 2010, pp. 29-34, https://ijcr.info/index.php/journal/article/view/9.

Issue

Volume 1, Issue 1, 2010

Section

Research Article
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