SYNTHESIS, SPECTRAL AND ANTIBACTERIAL STUDIES OF 18- MEMBERED TETRAAZAMACROCYCLIC COMPLEXES DERIVED FROM CARBOHYDRAZIDE AND DIACETONYL

Authors

  • M. KAMBOJ Department of Chemistry, Amity School of Engineering and Technology, Amity campus, Lucknow 226010, India
  • D. P. SINGH Department of Chemistry, National Institute of Technology, Kurukshetra 136119, India
  • K. JAIN Department of Chemistry, M.L.N. College, Yamunanagar 135001, India

Keywords:

Antibacterial activity, Carbohydrazide, Macrocyclic complexes, Template condensation.

Abstract

A novel series of the macrocyclic complexes of type [M(C14H24N8O2)X]X2, where M = Fe(III) or Cr(III) and X = Cl-1, NO3-1 or CH3COO-1 has been synthesized by [2+2] condensation of carbohydrazide and acetonylacetone (diacetonyl) in the presence of trivalent metal salt in methanolic medium. The complexes were characterized with the help of various physicochemical techniques such as elemental analyses, conductance measurements, electronic and infrared spectral studies. The low value of molar conductance indicates them to be as 1:2 electrolytes. On the basis of various studies, a five coordinate square pyramidal geometry for these complexes has been proposed. All the synthesized macrocyclic complexes were also tested for their in vitro antibacterial activity against some pathogenic bacterial strains. The MIC values shown by the complexes against these bacterial strains were compared with those of the standard antibiotics Ciprofloxacin. Some of the complexes showed good antibacterial activities

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Published

01-01-2012

How to Cite

KAMBOJ, M., D. P. SINGH, and K. JAIN. “SYNTHESIS, SPECTRAL AND ANTIBACTERIAL STUDIES OF 18- MEMBERED TETRAAZAMACROCYCLIC COMPLEXES DERIVED FROM CARBOHYDRAZIDE AND DIACETONYL”. International Journal of Chemistry Research, vol. 3, no. 1, Jan. 2012, pp. 21-24, https://ijcr.info/index.php/journal/article/view/70.

Issue

Section

Research Article