MICROWAVE-ASSISTED SYNTHESIS OF SOME QUINOLINE ALKALOIDS: MONTONINE, 4-METHOXYQUINOLINE-2(1H)-ONE AND ITS ANALOGUES
Keywords:Edulitine, Quinolines, Alkaloids, Phase transfer catalyst, Microwave.
The microwave synthesis of quinoline alkaloid montonine 2a and its analogues 2b-e was achieved in 6-8 min by methoxydechlorination of 2,4-
dichloroquinolines 1a-e using TBAB as phase transfer catalyst. Selective hydrolysis of 2a-e by sodium acetate/acetic acid afforded 4-
methoxyquinolin-2(1H)-one 3a and its derivatives including natural alkaloid edulitine