SIMPLE EXTRACTIVE COLORIMETRIC DETERMINATION OF PANTOPRAZOLE SODIUM BY ACID­DYE COMPLEXATION METHOD IN SOLID DOSAGE FORM

Authors

  • R. KALAICHELV K.C.Reddy Institute of Pharmaceutical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur­522 348, India.
  • M. FATIMA ROSE SIMS College of Pharmacy, Mangaldas Nagar, Guntur­522 001, India.
  • K. VADIVEL SIMS College of Pharmacy, Mangaldas Nagar, Guntur­522 001, India.
  • E. JAYACHANDRAN S.C.S. College of Pharmacy, Harapanahalli­583131. Devanagari Dist, Karnataka.

Keywords:

Spectrophotometry, Pantoprazole sodium, Bromothymol blue, Ion‐association complex

Abstract

A simple and sensitive extractive spectrophometric method has been described for the assay of pantoprazole sodium either in pure form or in
pharmaceutical solid dosage form. The developed method involves formation of colored chloroform extractable ion‐association complex of
pantoprazole sodium with bromothymol blue in aqueous acidic medium. The extracted complexes showed absorbance maxima at 428 nm. Beer’s
law is obeyed in the concentration range of 10‐50 μg mL‐1. Correlation coefficient was found to be 0.9997. The proposed method is useful for the
routine estimation of pantoprazole sodium in bulk and tablet dosage form. Results of analysis were validated statistically. The excipients present in
the formulations do not interfere with the assay procedure.

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Published

01-01-2010

How to Cite

KALAICHELV, R., M. F. ROSE, K. VADIVEL, and E. JAYACHANDRAN. “SIMPLE EXTRACTIVE COLORIMETRIC DETERMINATION OF PANTOPRAZOLE SODIUM BY ACID­DYE COMPLEXATION METHOD IN SOLID DOSAGE FORM”. International Journal of Chemistry Research, vol. 1, no. 1, Jan. 2010, pp. 6-8, https://ijcr.info/index.php/journal/article/view/2.

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Section

Research Article