DNA INTERACTION STUDIES, ANTIMICROBIAL AND ANTHELMINTIC ACTIVITY OF SULFONAMIDES OF 1, 3­DIOXOLANE AND 3,4­DIHYDROQUINOLIN­2(1H)­ONE ANALOGUES: SYNTHESIS AND CHARACTERIZATION

Authors

  • H. D. REVANASIDDAPPA Department of Chemistry, University of Mysore, Manasagangotri, Mysore ­570 006, Karnataka, India
  • K. SHIVA PRASAD Department of Chemistry, University of Mysore, Manasagangotri, Mysore ­570 006, Karnataka, India,
  • L. SHIVA KUMAR Department of Chemistry, University of Mysore, Manasagangotri, Mysore ­570 006, Karnataka, India
  • K. B. VINAY Department of Chemistry, University of Mysore, Manasagangotri, Mysore ­570 006, Karnataka, India,
  • S. CHANDRA SHEKAR Department of Biotechnology, University of Mysore, Manasagangotri, Mysore ­570 006, Karnataka, India
  • B. JAYALAKSHM Department of Botany, MSCW, Mysore­570005, Karnataka, India

Keywords:

3,4‐dihydroquinolin‐2(1H)‐one, antibacterial activity, anthelmintic activity and DNA interaction.

Abstract

A series of sulfonamide group containing compounds were synthesized by the reaction of 2‐dimethylaminomethyl‐1,3‐dioxolane, I and 7‐hydroxy‐
3,4‐dihydroquinolin‐2(1H)‐one, II with appropriate substituted sulfonyl chlorides, IIIa­e. The structural elucidation of these compounds is based on
IR, 1H‐NMR, mass spectral data and elemental analysis. The synthesized compounds were tested for antimicrobial activity by disc diffusion method.
Anthelmintic activity of the compounds has been tested on earthworms and few of the compounds show moderate activity. The DNA binding of the
compounds IVa and Va with CT‐DNA has been performed with absorption spectroscopy, which reveals that both the compounds show less binding
propensity towards CT‐DNA. Also the nuclease activity of complexes IVa and Va with plasmid DNA (PUC 19) was studied using agarose gel
electrophoresis. The compound Va can act as effective DNA cleaving agent when compared to compound IVa resulting in the nicked form of DNA
under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent

Downloads

Download data is not yet available.

Published

01-01-2011

How to Cite

REVANASIDDAPPA, H. D., K. S. PRASAD, L. S. KUMAR, K. B. VINAY, S. C. SHEKAR, and B. JAYALAKSHM. “DNA INTERACTION STUDIES, ANTIMICROBIAL AND ANTHELMINTIC ACTIVITY OF SULFONAMIDES OF 1, 3­DIOXOLANE AND 3,4­DIHYDROQUINOLIN­2(1H)­ONE ANALOGUES: SYNTHESIS AND CHARACTERIZATION”. International Journal of Chemistry Research, vol. 2, no. 1, Jan. 2011, pp. 1-6, https://ijcr.info/index.php/journal/article/view/19.

Issue

Section

Research Article

Similar Articles

You may also start an advanced similarity search for this article.