SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF 2[4­(2,3­ DICHLOROPHENYL) PIPERAZINE­1­YL) METHYL] ­3­[8­HYDROXIDE QUINOLINE­5­YL]­3­ (H)­QUINAZOLIN­4­ONE LIGAND AND ITS METAL CHELATES

Abstract

The novel ligand HL7 was synthesized using 2‐Chloromethyl‐3‐(8‐hydroxyquinolin‐5‐yl)‐3(H)‐ quinozolin‐4‐one and it was undergo the chelating
reaction with Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) to prepare transition metal chelates. These chelates were characterized by physicochemical
methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT‐IR, NMR and electronic spectral data. The stoichiometry of
the complex has been found to be 1: 2 (Metal: ligand). An octahedral geometry around Co(II), Ni(II) and Mn(II), distorted octahedral geometry
around Cu(II) and tetra hedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates was conducted
against various fungi.