A REVIEW ON PHYTOCHEMISTRY AND PHARMACOLOGY OF CALYCOPTERIS FLORIBUNDA ROXB. LAM
The medicinal plant Calycopteris floribunda Roxb. Lam. commonly known as “Ukshi” belongs to the family Combretaceae. Calycopteris floribunda is a large evergreen climbing shrub native of Bangladesh and India. It is widely distributed in the central and southern parts of India and also found in south-east Asian countries. The branches store abundant water for its own purpose as well to quench the thirst of the forest dwellers. Hence the forest habitants are referring this plant as a lifesaver. Calycopteris floribunda finds a place in traditional Asian medicinal systems, including Ayurveda, Folk and Unani. The anti-inflammatory flavonoid compound calycopterin is present in the leaves of the plant. In Ayurveda this plant is used to treat for leprosy, malarial fever, dysentery, ulcers, vomiting, wound healing and cytotoxic. It is hepatoprotective, antimicrobial, antiviral and used for numerous ailments. A review on the medicinal plant Calycopteris floribunda was done in the period from 1934 to 2020. Here, we are focusing on the isolation, phytochemical constitution and pharmacological potential of Calycopteris floribunda plant.
2. Stuffness M, J Douros. Current status of the NCI plant and animal product program. J Nat Prod 1982;45:1-14.
3. Yusuf M, Choudhury JU, Wahab MA, Begum J. Medicinal plants of Bangladesh. Bangladesh Council of Scientific and Industrial Research. Dhaka, Bangladesh; 1994. p. 1-340.
4. Bhat PR, Prajna PS, Kumar V, Hegde MA, Singh L. Antimicrobial properties of leaves of Calycopteris floribunda lam. J Med Plants Res 2011;5:2448-51.
5. Kirthikar KR, Basu BD. Indian medicinal plants. 2nd Volume Uttaranchal, India: Oriental Enterprises; 2001. p. 1441-3.
6. Sreekanth P, Narayana K, Shridhar NB, Bhat A. Toxicity studies of Calycopteris ﬂoribunda lam. in calf, rabbit and rat. J Ethnopharmacol 2006;107:229-33.
7. Dey SK, Mohammed S, Tamanna R, Nahar N, Mosihuzzaman M, Sultana N. Biological and chemical studies of Calycopteris floribunda leaves. Dhaka Univ J Pharm Sci 2005;4:1816-39.
8. Santharam B, Ganesh P, Soranam R, Divya VV, Lekshmi NCJP. Evaluation of in vitro free radical scavenging potential of various extracts of whole plant of Calycopteris floribunda (Lam.). J Chem Pharm Res 2015;7:860-4.
9. Vinayaka KS, Rajakumar N, Kekuda TRP, Roopashree AC. Comparative antibacterial efficacy of methanol and aqueous extracts of Calycopteris floribunda (Roxb.) poiret. Adv Plant Sci 2011;24:39-41.
10. Ratnagiriswaran AN, Sehra KB, Venkataraman K. The anthelminthic constituent of the leaves of Calycopteris floribunda. Biochem J 1934;28:1964−7.
11. Shah RC, Virkar VV, Venkataraman K. The constitution of calycopterin, the yellow coloring matter of the leaves of Calycopteris floribunda. J Indian Chem Soc 1942;19:135-8.
12. Khorana ML, Motiwala DK. Anthelmintics isolation of Calycopteris floribunda. Indian J Pharm 1948;10:98-9.
13. Gupta SR, Seshadri TR, Sood GR. Flavonols and other compounds of the leaves of Calycopteris floribunda. Phytochemistry 1973;12:2539-40.
14. Muhamed KS, Neelakantan S, Raman PV. Chemical components of Indian medicinal plants (Thespesia populnea wood and Calycopteris floribunda flowers). Curr Sci 1975;44:888-9.
15. Rao AVR, Varadan M. Calycopeterin 4’-methyl ether and 3’-methoxycalycopterin in the leaves of Calycopteris floribunda. Indian J Chem 1973;11:403-4.
16. Ali H, Chowdhury AKA, Rahman AKM, Borkowski T, Nahar L, Sarker SD. Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro. Phytother Res 2008;22:1684-7.
17. Liu X, Yang DL, Liu JJ, Xu K, Wu GH. Modeling of supercritical fluid extraction of flavonoids from Calycopteris floribunda leaves. Chem Papers 2014;68:316-23.
18. Mayer R. Calycopterones and calyflorenones, novel biflavonoids from Calycopteris floribunda. J Nat Prod 1999;62:1274-8.
19. Mayer R. Five biflavonoids from Calycopteris floribunda (Combretaceae). Phytochemistry 2004;65:593-601.
20. Lewin G, Shridhar NB, Aubert G, Thoret S, Dubois J, Cresteil T. Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda lamk. Bioorganic Med Chem 2011;19:186-96.
21. Wall ME, Wani MC, Fullas F, Oswald JB, Brown DM, Santisuk T, et al. Plant antitumor agents the calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines. J Med Chem 1994;37:1465-70.
22. Vinayaka KS, Kekuda TRP, Shivakumar B, Shravanakumara S. Anti-dermatophyte activity of methanol and aqueous extracts of Calycopteris floribunda (Roxb.) poiret leaves. Nat Prod 2009;5:215-9.
23. Vinayaka KS, Rajakumar N, Kekuda TRP, Roopashree AC. Comparative antibacterial efficacy of methanol and aqueous extracts of Calycopteris floribunda (Roxb.) poiret. Adv Plant Sci 2011;24:39-41.
24. Satyanarayana T, Eswaraiah MC. In vitro antioxidant and free radical scavenging potential of stem of Calycopteris floribunda lam. Res J Pharm Biol Chem Sci 2010;1:117-23.
25. Kumar KAR, Pavithra GM, Junaid S, Rakesh KN, Dileep N, Siddiqua S, et al. Elemental analysis and anticariogenic activity of flowers of Calycopteris floribunda, Humboldtia brunonis and Kydia calycina. Asian J Res Chem 2013;6:623-7.
26. Glory A, Judin J, Vasudevan R, Sumathi P. Preliminary phytochemical content and antibacterial activity of ukshi (Calycopteris floribunda lam.) leaves. J Med Plants Studies 2016;4:57-9.
27. Vantamuri AB, Sounshi YB, Kotresh O, Dodamani S. A preliminary study on total phenolic content and antioxidant activities of Calycopteris floribunda root extracts. Int J Pharm Sci Res 2018;9:3020-3.
28. Pavithra GM, Naik AS, Siddiqua S, Vinayaka KS, Kekuda PTR, Mukunda S. Antioxidant and antibacterial activity of flowers of Calycopteris floribunda (Roxb.) poiret, Humbpldtia brunonis wall and Kydia Calycina roxb. Int J Drug Dev Res 2013;5:99-102.
29. Jia Jia L, Dong liang Y, Yan Z, Yao Y, Fu Xiang C, Jian Ming Z, et al. Chemical component and antimicrobial activity of volatile oil of Calycopteris floribunda. J Cent South Univ Technol 2009;16:931−5.
30. Pavithra GM, Dileep N, Rakesh KN, Syed J, Kekuda TRP, Vinayaka KS, et al. Inhibitory activity of flowers of Calycopteris floribunda, Humboldtia brunonis and Kydia calycina against fungal pathogens causing rhizome root of ginger. Bio Technol 2014;9:11-3.
31. Satyanarayana T, Eswaraiah MC, Bharathi A, Sriniva M. Anti-inflammatory activity of stem of Calycopteris floribunda. J Pharm Chem 2009;3:57-9.
32. Thalla S, Tammu J, Delhiraj N, Kumar KS. Hypoglycemic activity of hydro-alcoholic extract of Calycopteris floribunda Induced by streptozotocin in rats. Int J Pharm Sci Drug Res 2012;4:250-2.
33. Eswaraiah MC, Satyanarayana T. Hepatoprotective activity of extracts from stem of Calycopteris floribunda lam against carbon tetrachloride induced toxicity in rats. Int J Pharmacogn Phytochem Res 2010;2:53-7.
34. Kuvar SD, Shinde RD. Plants used by kokni tribe as antidote for snake bite and scorpion sting from Nasik and Dhule Districts of Maharashtra. J Global Biosci 2019;8:6043-50.
35. Natarajan B, Paulsen BS. An ethnopharmacological study from Thane District, Maharashtra, India: traditional knowledge compared with modern biological science. Pharm Biol 2000;38:139–51.
36. Kulal C, Padhi RK, Venkatraj K, Satpathy KK, Mallaya SH. Study on trace elements concentration in medicinal plants using EDXRF technique. Biol Trace Element Res 2020;198:293-302.
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