SYNTHESIS OF SOME NOVEL METHYL­2­(2­ (ARYLIDENEAMINO) OXAZOL­4­ YLAMINO) BENZOXAZOLE­5­CARBOXYLATE DERIVATIVES AS ANTIMICROBIAL AGENTS

Abstract

A series of methyl‐2‐(arylideneamino) oxazol‐4ylamino) benzoxazole‐5‐carboxylate derivatives (a–i) were synthesized and their antimicrobial
activities determined in comparison to several control drugs. The synthesized compounds were tested in vitro against Staphylococcus aureus, and
Bacillus subtilis as Gram‐positive, S.typhi and Escherichia coli as Gram‐negative bacteria and the yeast Candida albicans and A.niger. Microbiological
results showed that the compounds possessed a diffuse spectrum of antibacterial activity against these microorganisms. Compound VIIe which
bears a methoxy moiety at position 4‐of phenyl ring at the 2‐position of benzoxazole ring was the most active derivative against S. aureus, Bacillus
subtilis, S.typhi, Escherichia coli, Candida albicans and A.niger. Compound VIIg provided higher potency than the other tested compounds against
both antibacterial and antifungal organisms.