DEVELOPMENT AND VALIDATION OF NEW RP­HPLC METHOD FOR DETERMINATION OF PIOGLITAZONE HCL IN PHARMACEUTICAL DOSAGE FORMS

Authors

  • D. SRINIVASULU University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam
  • B. S. SASTRY University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam
  • G. OMPRAKASH University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam

Keywords:

Pioglitazone HCL, RP‐HPLC

Abstract

A simple and precise RP‐HPLC method was developed and validated for the determination of Pioglitazone hydrochloride in pharmaceutical dosage
forms. Chromatography was carried out using C18 column (250x4.6mm), mixture of Buffer: acetonitrile (55:45%v/v) as the mobile phase at a flow
rate 1.0 ml/min. The analyte was monitored using UV detector at 254 nm .The Retention time of the drug was 9.738min for Pioglitazone HCl. The
proposed method was found to have linearity in the concentration range of 0.1‐0.6 μg/ml with correlation coefficient of r2=0.9999. The developed
method has been statistically validated and found simple and accurate. The mean recoveries obtained for Pioglitazone HCL were in the range
100.09‐103.11%. Due to its simplicity, rapidness, high precision and accuracy of the proposed method it may be used for determining Pioglitazone
HCL in bulk and dosage forms.

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Published

01-01-2010

How to Cite

SRINIVASULU, D., B. S. SASTRY, and G. OMPRAKASH. “DEVELOPMENT AND VALIDATION OF NEW RP­HPLC METHOD FOR DETERMINATION OF PIOGLITAZONE HCL IN PHARMACEUTICAL DOSAGE FORMS”. International Journal of Chemistry Research, vol. 1, no. 1, Jan. 2010, pp. 18-20, https://ijcr.info/index.php/journal/article/view/6.

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Section

Research Article

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