SYNTHESIS AND CHARACTERIZATION OF BOC-PROTECTED THIO-1,3,4-OXADIAZOL-2-YL DERIVATIVES

Authors

  • S. SYED SHAFI Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore, India
  • R. RAJESH Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore, India, Department of Chemistry, Arunai Engineering College, Tiruvannamalai, India
  • S. SENTHILKUMAR Department of Chemistry, Arunai Engineering College, Tiruvannamalai, India

DOI:

https://doi.org/10.22159/ijcr.2021v5i3.169

Keywords:

(S)-2-amino-2-phenylacetic acid, Crystallization, Optical activity

Abstract

Objective: The objective of this work is to synthesis thio-1,3,4-oxadiazol-2-yl derivatives for industrial applications.

Methods: The synthesis was done by the reaction of (S)-2-amino-2-phenylacetic acid with ethanol-derived ethyl (S)-2-amino-2-phenylacetate. The reaction of ethyl (S)-2-amino-2-phenylacetate with Boc anhydride and hydrazine produces ethyl (S)-2-((tert-butoxycarbonyl)amino)-2-phenylacetate. The intermediate 5-alkyl amino-1,3,4-oxadiazole-2-thiols have been isolated as stable compounds.

Results: To study the characteristics of these compounds, they are subjected to 1HNMR, 13CNMR, and IR. These studies examine the chemical structure of synthesized compounds. The mass of the novel compounds was established with the help of the LCMS test. The structural and optical properties were examined by the powder XRD and photoluminescence spectrum respectively.

Conclusion: The sharp intense peak in the powder XRD indicates the crystal nature of the sample. The values obtained from the LCMS test indicate that the compounds have good thermal stability. The absorption peak at 358 nm in the PL spectrum indicates that the sample can be used in photoelectronic devices.

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Published

01-07-2021

How to Cite

SHAFI, S. S., R. RAJESH, and S. SENTHILKUMAR. “SYNTHESIS AND CHARACTERIZATION OF BOC-PROTECTED THIO-1,3,4-OXADIAZOL-2-YL DERIVATIVES”. International Journal of Chemistry Research, vol. 5, no. 3, July 2021, pp. 5-10, doi:10.22159/ijcr.2021v5i3.169.

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Research Article