SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SILVER (I) MEBENDAZOLE COMPLEXES

Authors

  • OLUFUNSO O. ABOSEDE Department of Chemistry, Federal University Otuoke, PMB 126, Yenagoa, Bayelsa State, Nigeria https://orcid.org/0000-0001-8477-270X
  • LOVETH E. EZEGWU Department of Chemistry, Federal University Otuoke, PMB 126, Yenagoa, Bayelsa State, Nigeria

DOI:

https://doi.org/10.22159/ijcr.2022v6i2.203

Keywords:

Synthesis and spectroscopic, Silver (I) mebendazole complexes

Abstract

Objective: The aim of this research work is to synthesize silver-mebendazole complexes with imidazole (imi), 2,2-bipyridine (bpy) and 1,10-phenanthroline (phen) as secondary ligands that will be active and effective against microbes.

Methods: Environmentally friendly techniques were employed to synthesize the new complexes by reacting silver nitrate and ligands in water and at ambient conditions. The formed complexes were isolated and dried at ambient conditions and characterized by UV and FTIR spectroscopies; the physicochemical and antimicrobial properties of the complexes against Proteus mirabilis and Salmonella typhi were also tested by agar well diffusion method.

Results: Spectroscopic studies confirmed the formation of the complexes. In the newly synthesized complexes, silver is coordinated by N of the imidazole moiety of mebendazole as well as N atoms of imidazole, 2,2-bipyridine and 1,10-phenanthroline. The complexes are stable and possess low aqueous solubility. Antimicrobial analyses revealed that they were active against the tested organisms with antibacterial activities higher than the parent drug, mebendazole.

Conclusion: The newly synthesized complexes were stable and the results show their antimicrobial potential. The resultant antimicrobial activity of the complexes is as a result of synergistic activities of silver and the ligands.

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References

Brugmans JP, Thienpont DC, van Wijngaarden I, Vanparijs OF, Schuermans VL, Lauwers HL. Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects. JAMA. 1971;217(3):313-6. doi: 10.1001/jama.1971.03190030039008, PMID 5109194.

Chai JY, Jung BK, Hong SJ. Albendazole and mebendazole as anti-parasitic and anti-cancer agents: an update. Korean J Parasitol. 2021;59(3):189-225. doi: 10.3347/kjp.2021.59.3.189, PMID 34218593.

Huang L, Zhao L, Zhang J, He F, Wang H, Liu Q, Shi D, Ni N, Wagstaff W, Chen C, Reid RR, Haydon RC, Luu HH, Shen L, He TC, Tang L. Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways. Aging (Albany, NY). 2021;13(13):17407-27. doi: 10.18632/aging.203232, PMID 34232919.

Son DS, Lee ES, Adunyah SE. The antitumor potentials of benzimidazole anthelmintics as repurposing drugs. Immune Netw. 2020;20(4):e29. doi: 10.4110/in.2020.20.e29. PMID 32895616.

Frei A, Zuegg J, Elliott AG, Baker M, Braese S, Brown C, Chen F, G Dowson C, Dujardin G, Jung N, King AP, Mansour AM, Massi M, Moat J, Mohamed HA, Renfrew AK, Rutledge PJ, Sadler PJ, Todd MH, Willans CE, Wilson JJ, Cooper MA, Blaskovich MAT. Metal complexes as a promising source for new antibiotics. Chem Sci. 2020;11(10):2627-39. doi: 10.1039/c9sc06460e, PMID 32206266.

Medici S, Peana M, Crisponi G, Nurchi VM, Lachowicz JI, Remelli M, Zoroddu MA. Silver coordination compounds: a new horizon in medicine. Coord Chem Rev. 2016;327-328:349-59. doi: 10.1016/j.ccr.2016.05.015.

Dai T, Huang YY, Sharma SK, Hashmi JT, Kurup DB, Hamblin MR. Topical antimicrobials for burn wound infections. Recent Pat Antiinfect Drug Discov. 2010;5(2):124-51. doi: 10.2174/157489110791233522, PMID 20429870.

Waszczykowska A, Zyro D, Ochocki J, Jurowski P. Clinical application and efficacy of the silver drug in ophthalmology: A literature review and new formulation of EYE drops with drug silver (I) complex of metronidazole with the improved dosage form. Biomedicines. 2021;9(2):210. doi: 10.3390/biomedicines9020210, PMID 33669740.

Trieu A, Mohamed A, Lynch E. Silver diamine fluoride versus sodium fluoride for arresting dentine caries in children: a systematic review and meta-analysis. Sci Rep. 2019;9(1):2115. doi: 10.1038/s41598-019-38569-9. PMID 30765785.

Peng JJ, Botelho MG, Matinlinna JP. Silver compounds used in dentistry for caries management: a review. J Dent. 2012;40(7):531-41. doi: 10.1016/j.jdent.2012.03.009. PMID 22484380.

Lansdown ABG. A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. Adv Pharmacol Sci. 2010. p. 16. doi: 10.1155/2010/910686, PMID 21188244.

Khatoon N, Alam H, Khan A, Raza K, Sardar M. Ampicillin silver nanoformulations against multidrug-resistant bacteria. Sci Rep. 2019;9(1):6848. doi: 10.1038/s41598-019-43309-0, PMID 31048721.

Rusu A, Hancu G, Cristina Munteanu A, Uivarosi V. Development perspectives of silver complexes with antibacterial quinolones: successful or not? J Organomet Chem. 2017;839:19-30. doi: 10.1016/j.jorganchem.2017.02.023.

Liang X, Luan S, Yin Z, He M, He C, Yin L, Zou Y, Yuan Z, Li L, Song X, Lv C, Zhang W. Recent advances in the medical use of silver complex. Eur J Med Chem. 2018;157:62-80. doi: 10.1016/j.ejmech.2018.07.057, PMID 30075403.

Kuzderova G, Rendosova M, Gyepes R, Sovova S, Sabolova D, Vilkova M, Olejnikova P, Bacova I, Stokic S, Kello M, Vargova Z. Antimicrobial and anticancer application of silver (I) dipeptide complexes. Molecules. 2021;26(21):6335. doi: 10.3390/molecules26216335, PMID 34770744.

Vashi RT, Shelat CD. Synthesis, characterization and antifungal activity of 2[4¬(2,3-dichlorophenyl) piperazine¬1-yl methyl ¬3¬[8¬hydroxide quinoline¬5¬yl]¬3¬ (h)¬quinazolin¬4¬one ligand and its metal chelates. Int J Chem Res. 2010 Jan 1;1(2):11-4.

Heidari A. Investigation of cancer cells using thin layers of cadmium oxide (cdo)–dna/rna sandwiched complex composite plasmonic nanostructure under synchrotron radiation. Int J Chem Res. 2022 Mar 25;6(1):1-14. doi: 10.22159/ijcr.2022v6i1.180.

Direm A, Abdelbaky MSM, Sayın K, Cornia A, Abosede O, Garcia Granda S. Sev and pcu topological nets in one-pot newly synthesized mixed-ligand imidazole-containing Cu(II) coordination frameworks: crystal structure, intermolecular interactions, theoretical calculations, magnetic behavior and biological activity. Inorg Chim Acta. 2018;478:59-70. doi: 10.1016/j.ica.2018.03.011.

Chen J, Wang Z, Wu C, Li S, Lu T. Crystal engineering approach to improve the solubility of mebendazole. Cryst Eng Comm. 2012;14(19):6221-9. doi: 10.1039/c2ce25724f.

Calvo NL, Kaufman TS, Maggio RM. Mebendazole crystal forms in tablet formulations. An ATR-FTIR/chemometrics approach to polymorph assignment. J Pharm Biomed Anal. 2016 Apr 15;122:157-65. doi: 10.1016/j.jpba.2016.01.035. PMID 26874854.

Published

01-04-2022

How to Cite

ABOSEDE, O. O., and L. E. EZEGWU. “SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SILVER (I) MEBENDAZOLE COMPLEXES”. International Journal of Chemistry Research, vol. 6, no. 2, Apr. 2022, pp. 1-5, doi:10.22159/ijcr.2022v6i2.203.

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Section

Research Article