• OLUFUNSO O. ABOSEDE Department of Chemistry, Federal University Otuoke, PMB 126, Yenagoa, Bayelsa State, Nigeria
  • LOVETH E. EZEGWU Department of Chemistry, Federal University Otuoke, PMB 126, Yenagoa, Bayelsa State, Nigeria



Synthesis and spectroscopic, Silver (I) mebendazole complexes


Objective: The aim of this research work is to synthesize silver-mebendazole complexes with imidazole (imi), 2,2-bipyridine (bpy) and 1,10-phenanthroline (phen) as secondary ligands that will be active and effective against microbes.

Methods: Environmentally friendly techniques were employed to synthesize the new complexes by reacting silver nitrate and ligands in water and at ambient conditions. The formed complexes were isolated and dried at ambient conditions and characterized by UV and FTIR spectroscopies; the physicochemical and antimicrobial properties of the complexes against Proteus mirabilis and Salmonella typhi were also tested by agar well diffusion method.

Results: Spectroscopic studies confirmed the formation of the complexes. In the newly synthesized complexes, silver is coordinated by N of the imidazole moiety of mebendazole as well as N atoms of imidazole, 2,2-bipyridine and 1,10-phenanthroline. The complexes are stable and possess low aqueous solubility. Antimicrobial analyses revealed that they were active against the tested organisms with antibacterial activities higher than the parent drug, mebendazole.

Conclusion: The newly synthesized complexes were stable and the results show their antimicrobial potential. The resultant antimicrobial activity of the complexes is as a result of synergistic activities of silver and the ligands.


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How to Cite

ABOSEDE, O. O., and L. E. EZEGWU. “SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF SILVER (I) MEBENDAZOLE COMPLEXES”. International Journal of Chemistry Research, vol. 6, no. 2, Apr. 2022, pp. 1-5, doi:10.22159/ijcr.2022v6i2.203.



Research Article